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Showing posts with label telomeres. Show all posts
Showing posts with label telomeres. Show all posts

Cracking the telomere code: The first step to reverse aging

4th International Conference on Tissue Science and Regenerative Medicine


July 27-29, 2015 Rome, Italy

 Al Sears

Scientific Tracks AbstractsJ Tissue Sci Eng

Abstract :

This lecture explores the discovery of the telomerase enzyme and its role as a crucial indicator of health and longevity. By tracing the evolution of telomere research, including the landmark Harvard study that fully restored youthful function in mice by activating the telomerase enzyme, Dr. Sears unveils the true age-reversing, and health-transforming potential of telomere therapy and the capacity to influence gene expression through novel interventions. As one of the only medical doctors to administer the world?s first telomere therapy, Dr. Sears relates its effects on his own patients, and how his own research uncovered new, more effective ways of supporting telomere length and altering telomere biology. Three learner objectives. By the end of the lecture, participants will understand: ? The evidence that supports the telomere?s role as the true cause of aging. ? What factors cause the telomere to shorten, and the most reliable interventions to support telomere length. ? How the search for telomerase activators uncovered new, more powerful and more affordable means of affecting telomere regulation.

Biography :

Al Sears, M.D. is the founder of the Center for Health and Wellness, a successful integrative medicine and anti-aging facility in Royal Palm Beach, Florida, with over 25,000 patients. His cutting-edge therapies and reputation for solving some of the most difficult-to-diagnose cases attract patients from around the world. Sears was one of the first to be board-certified in anti-aging medicine. As a pioneer in this new field of medicine, he is an avid researcher, published author, and enthusiastic lecturer.Sears is board-certified as a clinical nutrition specialist and a member of the American College of Sports Medicine (ACSM), the American College for the Advancement in Medicine (ACAM), the American Medical Association (AMA), the Southern Medical Association (SMA), the American Academy of Anti-Aging Medicine (A4M), and the Herb Research Foundation, (HRF). Dr. Sears is also an ACE-certified fitness trainer.Sears currently writes and publishes the monthly e-Newsletter, Health Confidential, and daily email broadcast, Doctor?s House Call, and contributes to a host of other publications in the field. He has appeared on over 50 national radio programs, ABC News, CNN, and ESPN.Since 1999, Dr. Sears has published 15 books and reports on health and wellness with a readership of millions spread over 163 countries.


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Support Telomere Length

The results confirm and expand previous work on the genetics of telomere length, while acknowledging that the effect of lithium may be limited to a small number of cells in the human body, rather than the entire body. Although ageing is a complex process, we have found a clear - and well-defined - biomarker of ageing at the cellular level: the length of telomerase, the protective layer of the cell. While researchers are linking aging and disease, the breed is in the process of understanding the factors that determine the length of the teloreceptor. We note that our results provide the first direct evidence of the role of lithium in aging, which has been poorly understood at both cellular and molecular levels. Sources: 7, 9, 14, 16
In our study, current family and social support had a positive relationship with telomere length, but unsurprisingly not against the historical burden of childhood stress. However, this small study provides a good basis for recent research on the role of stress in the development of teloreceptors and the effects of lithium on telomerase. Alternatively, social support may play a protective role by buffering the effects of stress on telomere length, which shortens the rate of cell replication, and mitigating the negative effects of stress on telomeres. Sources: 5, 8
Understanding how telomere length is regulated is crucial to realizing the potential benefits of lithium in the development of teloreceptors and other cell types, "Rivera said. We focus on the role of stress and social support in supporting telitere structure and function in human health. Sources: 11, 14
On the surface, it seems desirable to strike a balance between maintaining and increasing telomere length and telomerase activity. Since telomeres can shorten in the context of aging and be maintained and prolonged by telomerase, it is logical that interventions modulating the telomerasing duo of teloreceptors represent a chance to prevent, delay, or minimize the degenerative diseases associated with age. Sources: 6, 11
However, it is unwise to say that increasing telomere length by pharmacological or nutraceutical means is advisable, as it can cause undesirable side effects. Sources: 6
Matt Kaeberlein, who studies the molecular basis of aging at the University of Washington, says: "By measuring telomere length in the blood, we are actually reporting a well-functioning immune stem cell. When we measure the length of a single cell, such as a blood stem cell, we need to think about how much work the stem cell does and how often it is supported by a particular tissue. Sources: 1, 2
Analysis of telomere structure, function and biology will be crucial to clarify the role of lithium in maintaining telomere length and structure. Vitamins C and E can limit the effects of the shortening of telotechnologies, such as those found in blood stem cells, on short- and long-term telomeres. On the other hand, the critical telomerase length can lead to a fusion of the chromosomes by the NHEJ mechanism or to the telomeres uncapping. Future longitudinal studies to assess the effect of lithium on age - the associated disease risk is likely to be based on confirmation that gene transcripts are the primary mediator in lithium tele - will prolong the effects on teloneurons. Sources: 3, 9, 12
Finally, it should be borne in mind that genetic factors only make up a small proportion of the overall effect of lithium on telomere length and structure. It is difficult to interpret the effects of other factors such as age - specific changes in telomerase activity, given the age of each individual. Sources: 3, 6
Although it can take months or years for telomeres to change significantly, the authors write, "we should focus on maintaining healthy habits rather than being obsessed with telomerase activity at a certain point in time or telomere length," they write. It seems to be a matter of time before you stay healthy, not if you get an illness or actually die, but rather when. Sources: 15, 17
Previous laboratory and epidemiological findings support several plausible biological pathways, including changes in cell and immune function [22], and maternal stress during pregnancy is associated with shorter offspring telomeres [23]. However, this work does not cover cellular aging, such as telomerase length, as a marker. Finally, the study did not include an analysis of newborn telomere length, but was conducted in mammals, particularly in humans, which have little or no somatic telomerase production. Sources: 0, 8, 18
The current data show the importance of telomere length as a biomarker of cellular aging in the development of Alzheimer's disease. We are now studying dementia sufferers and seeing how various ways of reducing their stress can improve the biomarkers of ageing, including telomerase length. Sources: 8, 17
The possibility of offering telomere length as part of a genetic test is intriguing, because the genetic material that protects telomeres is protected by telomerase, the enzyme responsible for repairing the chromosomes in the cell. Sources: 13
Comparative genomic work has shown that lithium can moderate the expression of genes that control telomere length, and this may be a mechanism by which lithium prolongs telomeres in patients with bipolar disorder. This novel telomerase loop mechanism implies that progressive teliter shortening can affect cell physiology and age-related diseases, such as aging, as telomeres become incurably short and trigger DNA damage signals. Lifestyle is an important factor in telomyelitis, a disease of the heart, brain and spinal cord, so length could be an important determinant of a patient's long-term wellbeing. It might explain how some of us age more or less than others, with decisions we make every day. 

Cited Sources

Healthycell Telomere Length

Scientists from the Southwest hope to use telomere knowledge to slow or halt the aging of cells, potentially stopping cancer cells that retain their telomeres. A team of researchers from UT Southwestern University and the University of Texas Health Science Center San Antonio has found a new way to determine the length of telomere endcaps on chromosomes that can influence the progression and aging of cancer. Sources: 1, 3
Ultimately, understanding telomeres and telomerase will give us a better understanding of our health and possibly even ageing. The focus on immortality and anti-aging probably distracts us from the more important and accessible things. Sources: 8
The bottom line is that telomere length and its biology are as important as any other aspect of our health and the health of the cells in our bodies. There is nothing wrong with ageing biology and nothing to cut back on without worrying about telomerase or your telomeres. Sources: 8, 10
Telomeres can shorten due to many factors such as life stress, chronic diseases and infections. Anything that causes increased stress, such as immune system activation, stress hormones, high blood pressure or high cholesterol, can be associated with shorter telomere length. Living in an area considered a disturbed neighborhood can affect a child's well-being in many ways, from physical and mental health to mental and emotional health. Sources: 6, 9
The National Institute of Mental Health (NIMH), a division of the U.S. Centers for Disease Control and Prevention (CDC). Sources: 4
If you want to know more about how nutritional and lifestyle components affect cellular health and aging, you should test your telomeres with Life (r) to help you navigate and maintain the right path to a bright future. The results of this study suggest that daily administration of NS influences the length of whole and short telomeres in a positive way, regardless of gender and age. This study examined the effects of daily NS administration on length and length - of - complete - and - short - telomere length in men and women. The results of the study show that the association between NS and long-term health remained significant after age and gender were taken into account. Sources: 4, 10
Finally, it should be remembered that genetic factors are only a small part of the impact of diet and lifestyle factors on telomere length. This suggests that the mechanisms by which nutritional factors reduce the wear and tear of teliters need to be investigated for their role in the development of cellular health. Sources: 4, 10
A 2012 study showed that vitamin D3 improves telomere maintenance, prevents cell death, and prevents obesity - an acceleration of skin aging caused by mice. P53, p21, WAF and CIP pathways mediate oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Sources: 4, 6
Telomerase is expressed by stem cells (including those that produce sperm and eggs) to ensure that the telomeres in these cells remain at the top - in top shape for the next generation. When cells divide, telomeres shorten, and the gradual shortening of telomeres leads to age-related chronic diseases. DNA damage, in conjunction with other factors, can lead to increased likelihood of cancer, heart disease, diabetes, Alzheimer's, liver and kidney cancer and other diseases. Sources: 2, 3, 4
As time goes on, telomeres become shorter and shorter as cells divide again and again, and there is a critical point at which they become too short. The ability to divide cells is not eternal, but finite; the ability of a cell to divide cannot divide anymore and the cell dies. Biological death occurs when worn-out tissue cannot renew itself because the chromosomes are unprotected. Sources: 0, 10
The precise determination of what is needed to lengthen telomeres can have far-reaching health implications, as shortened telomeres are associated with cancer in heart disease, diabetes, cancer, Alzheimer's and Alzheimer's, and in cases of longer telomere length. Studies have shown that a healthy diet and the reduction of psychological stress can influence how quickly telomeres shorten or lengthen. In addition, a deficiency of vitamin B12 and folate can lead to insufficient calcium levels, which in turn can lead to a shortening of telomeres. Even small changes in the speed at which telomytes shorten can affect their length and lengthening and modify the risk of chronic diseases. Sources: 4, 7, 9
Long-term B1 deficiency can lead to high oxidative stress levels, with corresponding effects on telomere length, which has already been exposed to the effects of high stress levels such as high blood pressure and high cholesterol. Sources: 10
Telomere shortening can be reversed by the enzyme telomerase, which is active in highly proliferative cells such as activated lymphocytes and can also be prevented by avoiding "wear and tear" of the telomeres. This is one way cancer cells escape death, as they continue to divide abnormally and form more telomerase. Previous studies have shown that injecting the telomerase gene into immune cells (T cells) in the body can help prevent telomerases from becoming shorter and maintain their long-term health benefits of high B1 levels. This leads to a continuous telomere, which shortens when the cell becomes senescent. 

Cited Sources