Telomere - Wikipedia

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Showing posts with label foods that lengthen telomeres. Show all posts
Showing posts with label foods that lengthen telomeres. Show all posts

Mitochondrial Function: The Other Half Of The Anti-Aging Story

By Al Sears MD

Telomere science changed everything we knew about aging. But today, I want to talk to you about the other half of the anti-aging equation.
Regular readers will already know by protecting your telomeres, you can slow — and even reverse — the aging process.
You see, your telomeres are like little countdown clocks that protect the DNA in your cells. They shorten with each cell division. And the shorter they get the faster you develop the signs of aging. So by protecting and nourishing them, you can literally turn back the years.
I was one of the first doctors to put telomere science to the test. And for years, I’ve been helping patients measure, protect and lengthen their telomeres.
But I’ve also discovered that telomeres are only HALF the story when it comes to aging. Let me explain…
Telomeres protect the DNA inside the nucleus of each cell in your body. But there is other DNA in each of your cells outside the nucleus.
You see, your cells also contain tiny organelles called mitochondria. These are the power plants that turn fuel into energy. And your mitochondria have their own DNA and their own impact on the aging process.
Mainstream medicine still ignores the anti-aging power of mitochondria. But in today’s letter, I’m going to show you how to boost mitochondria while at home.
But first, let’s look at why your mitochondria are so important…
Each of your cells has at least one of these tiny power plants. The average cell has 200. And cells for important organs, like your heart and brain, can have more than 10,000.
But here’s the problem: As you age, these tiny power plants become damaged and start to die off. And you lose your capacity to make energy.
The first thing that happens is that your cellular energy takes a dive. You feel tired and fatigued. But then they malfunction, and devastating diseases can follow:
  • Schizophrenia and bipolar disease;
  • Alzheimer’s and Parkinson’s disease;
  • Epilepsy, migraines, and nerve pain;
  • Loss of muscle control and balance;
  • Heart disease and strokes;
  • Fibromyalgia;
  • Blindness;
  • Diabetes;
  • Hepatitis C and cirrhosis. 1
Today, this happens at a faster rate than what your parents and grandparents experienced because now we’re living in a highly toxic environment. And exposure to toxic chemicals can cause the body to age faster.
You see, today, we’re faced with “accelerated aging” because of environmental factors, such as cigarette smoke and ultraviolet rays from the sun. And its effect can age you prematurely.

But there are ways to support mitochondria…

Here at the Sears Institute for Anti-Aging Medicine, I help my patients prevent and repair damage to the mitochondria.
And I do this not with Big Pharma meds, but with nutrients. Here are just four of the nutrients I recommend that have been proven to support your mitochondrial function and boost energy.
  1. CoQ10: Co-enzyme Q10 sparks your aging cell engines to make more energy. And it’s a potent free radical scavenger, soaking up oxidized molecules before they cause damage.

    I recommend taking 50 mg of CoQ10 daily. Look for the ubiquinol form. It’s more powerful and much easier for your body to absorb.
  2. Acetyl-L-Carnitine: The amino acid L-carnitine plays a critical role in making energy in your cells. It transports fatty acids into the mitochondria. There they can be burned for fuel. It also carries toxic waste out before it can do damage.
    But as you age, carnitine levels in your tissues drop.2 That’s why you need acetyl-L-carnitine (ALC). Your body converts L-carnitine to ALC. And studies show when your mitochondria slow down, ALC can fire them up again.3 Studies also show ALC reverses the malfunction in mitochondria as you age. ALC can also improve brain performance and increase neurotransmitters.4
    The best source of L-carnitine is grass-fed red meat. But you can also supplement. I suggest taking at least 500 mg of ALC every day on an empty stomach. Look for a formula with only L-carnitine and not D, L-carnitine. D-carnitine is synthetic.
  3. N-Acetyl-Cysteine (NAC): This amino acid is also a powerful antioxidant. You see, NAC helps make glutathione, the body’s most powerful antioxidant. Glutathione is the main line of defense for mitochondria. It helps prevent and repair oxidative damage, thus protecting your mitochondria.6,7
    And there’s another reason I recommend NAC to my patients. Studies show it protects your telomeres from oxidative damage.8 So it throws a one-two anti-aging punch. I advise supplementing with 500 mg per day.
  4. Rhodiola Rosea: This tough, little yellow flower is native to the arctic mountains of Eastern Siberia. And I’ve seen its power to energize my patients. In just a few months, they are visibly younger and stronger. And they tell me they feel that way, too.
Research proves what I’ve seen in my patients. Lab Rats given rhodiola were able to swim 25% longer before becoming exhausted.9 That’s because the herb helped trigger energy synthesis in the mitochondria.
Rhodiola can also energize people. Just one 200 mg dose helped people in one study improve their exercise endurance.10 In another study, students taking 100 mg of rhodiola every day improved their capacity to work. Their learning ability increased by 61% and their fatigue levels dropped by 30%.11
You can find Rhodiola tea in your local health food store. Or you can take it in capsule form. It’s also called golden root or roseroot. But make sure you get a formula with enough of the herb’s active compounds. Look for an extract standardized to contain at least 3% rosavins and 1% salidroside. That’s the same ratio found in the natural root.
I recommend taking 200 mg a day on an empty stomach, preferably in the morning because rhodiola stimulates your brain.
I’ve been tinkering with a new formula to support your mitochondria. And it contains all the ALC, NAC, and rhodiola you need. So stay tuned.
To Your Good Health,
Al Sears, MD, CNS
1Neustadt J, Pieczenik SR. “Medication-induced mitochondrial damage and disease.” Mol Nutr Food Res. 2008;52(7):780-8.
2Opalka, J., Gellerich, F., Zierz, S. “Age and sex dependency of carnitine concentrations in human serum and skeletal muscle.” Clinical Chemistry, 2001, 47: 12, 2150-2153.
3Kidd PM. “Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management.” Altern Med Rev. 2005; 10(4):268-93.
4Hagen, TM., Wehr, CM., Ames, BN. “Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone.” Ann N Y Acad Sci, 1998;854:214-23.
5Arakawa M, Ito Y. “N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology.” Cerebellum. 2007;6(4):308-14.
6Montserrat Marí, Albert Morales, Anna Colell et al. “Mitochondrial Glutathione, a Key Survival Antioxidant.” Antioxid Redox Signal. 2009; 11(11): 2685–2700.
7Kelly GS “Clinical applications of N-acetylcysteine.” Altern Med Rev. 1998;3(2):114-27.
8Ludlow A, Spangenburg E, Chin E, Cheng W, Roth S. “Telomeres Shorten in Response to Oxidative Stress in Mouse Skeletal Muscle Fibers.” J Gerontol A Biol Sci Med Sci. 2014;69(7):821-30.
9Abidov M, Crendal F, Grachev S, et al. “Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles.” Bull Exp Biol Med. 2003;136(6):585-7.
10De Bock K, Eijnde BO, Ramaekers M, Hespel P. “Acute Rhodiola rosea intake can improve endurance exercise performance.” Int J Sport Nutr Exerc Metab. 2004;14(3):298-307.
11Spasov AA et al. “A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.” Phytomedicine. 2000;7(2):85-9.

Foods That Lengthen Telomeres

By Al Sears MD


In 1984 Dr. Elizabeth Blackburn discovered what may be the single most important anti aging discovery.

The Telomerase Enzyme.

Dr. Blackburn was awarded the Nobel Prize in Physiology and Medicine for this discovery.
I have personally known about the importance of Telomeres for years, but until recently the only known way to really boost the length of telomeres was an outrageously expensive supplement called T-65, that only the very rich could afford.
I am so excited to report that there are now scientifically proven simple ways that the average person can boost the length of their telomeres, which slows down the aging process.
I found out about these simple protocols through one of my trusted anti aging advisers,
Dr. Al Sears

Dr. Al Sears.

Dr. Sears is considered a pioneer in anti aging medicine. He operates a successful integrative medicine and anti-aging clinic in Florida with over 25,000 patients. He is famous for his cutting-edge therapies that solve some of the most difficult-to-diagnose cases.
Dr. Sears has written 14 books and over 100 reports on health and wellness. He is also the founder and director of the Wellness Research Foundation, a non-profit research organization.
Dr. Sears was the first doctor licensed to administer groundbreaking DNA therapy that activates the gene that regulates telomerase.
After reading his report on how to Activate the Enzyme that Rebuilds Your Telomeres, I realized that this is the reason my husband seems to be growing younger. You can read all about his journey back to health in Cathey’s Immune Boosting Tips.

You may be asking what are Telomeres and why should I care?

Deep inside every cell in your body is a strand of DNA with a “protective tip” similar to the protective tip of a shoelace. This “protective tip” called a telomere controls aging.
Everytime your cells divide, your telomeres get shorter, which causes you to age faster. Once you run out of telomeres, cell division stops and life comes to an end.
The goal then is to keep the telomeres as long as possible therefore slowing down the aging process so that you not only feel younger, you look younger and you may even live longer.

There are simple protocols that will activate, or turn on the Telomerase Enzyme that will “rebuild” your Telomeres.

As I mentioned earlier the supplement TA-65 is one way to “flip the switch” turning on the telomerase enzyme which will lengthen your telomeres. The cost is around $500 per month.


According to new studies this anti-aging nutrient “significantly increases telomerase activity” by “turning on” genes that promote longevity, and “turning off” genes that promote disease.
  • Resveratrol is found in
  • Red Wine
  • Purple Grape Juice
  • Mulberries
  • Raisins
  • Acai (I buy the organic freeze dried acai and put into my morning smoothies every day)
It is very hard to get enough Reserveratrol in your daily diet. (you would have to drink 1,000 glasses or more of red wine daily)
Dr. Sears recommends taking a Resveratrol supplement with around 10mg – 20 mg for optimal telomerase activation.

Green tea
Green Tea (EGCG)

In a study published in the British Journal of Nutrition, the telomeres of green tea drinkers were .46 kilobases longer. This is equal to about 5 years of life.
The EGCG in green tea can prevent and repair cell damage and fights the effects of pollution, sunlight and smoking.
Forget the bottled green tea drinks and go for the whole tea leaves sold in specialty tea stores.

N-Acetyl-Cystein (NAC)

NAC is a potent amino acid building block of the body’s master anti-oxidant called glutathione (GSH). NAC activates the telomerase gene, often called the “fountain of youth” gene.
Dr. Sears recommends a dose of 1,800mg – to 2,400 mg a day.
I personally take Pure Encapsulations NAC.
NutsAlpha Tocopherol
This is the most well-known from of vitamin e and will protect against telomere shortening.
Researchers from Finland believe that alpha tocopherol prevents cancer by neutralizing free radicals, protecting cells from oxidation and stopping damaged cells from multiplying.
The best way to get your Vitamin E is from food.
  • Nuts
  • Nut oils
  • Seeds
  • Apples
  • Beef
  • Seafood
  • Avocados
  • Spinach.

  • You can also take 400 IU of Vitamin E with mixed tocopherols.
  • I personally take Pure Encapsulations Ultra-Synergist E.

Carlson TocotrienolsGamma Tocotrienol

One of the four lesser known forms of vitamin E, Gama Tocotrienols can extend telomere length by 16%.
It is next to impossible to get enough tocotrienols from the few foods that contain them Dr. Sears recommends a supplement with at least 20 mg of “mixed tocotrienols”.
I recommend Carlson’s Tocotrienols.


Used to repair tissues and clear away toxins and it helps preserve your telomeres.

Grass fed, pasture raised meat is the best way to get carnosine from food.
If you don’t eat meat, Dr. Sears recommends taking a supplement of L-Carnosine
500 milligrams twice a day instead of all at once.


Increases telomerase activity by stimulating the production of nitric oxide (NO), the molecule that relaxes the blood vessels.
Body builders have been using l-arginine for years. Taken before a workout, it gives them a “muscle pump” by getting more blood and oxygen to their muscles.
Dr. Sears recommends 500mg – 1,000 mg per day.

Vitamin C

Vitamin C

There is now evidence that vitamin c not only prevents loss of telomeres, it also increases telomerase activity in specific stem cells.
Telomeres are very sensitive to oxidation and vitamin C prevents oxidation.
Food sources of vitamin C
  • Citrus fruits
  • Cantaloupe
  • Kiwi
  • Mango
  • Papaya
  • Pineapple
  • Berries
  • Watermelon
Dr. Sears recommends 540 mg per day. (I personally take 1500 mg per day)

sunbath for Vitamin D3

Vitamin D3

Crucial for boosting the immune system, Vitamin D also activates telomerase activity by as much as 19.2%.
One of the best ways to boost Vitamin D3 is to get in the sun at least 15 minutes 3 – 5 times per week.
You can also get Vitamin D from
  • Cod Liver Oil
  • Herring
  • Catfish
  • Salmon, cooked
  • Mackerel, cooked
  • Sardines, canned in oil, drained
  • Tuna, canned in oil

Milk Thislte

Milk Thistle (silymarin extract)

This ancient herb is known for it’s detoxifying benefits. Silymarin triples telomerase activity.
Dr. Sears recommends 200 mg in capsule form twice a day.

Ginkgo Bilboa

Ginko Biloba

Known as a brain booster because it helps open up blood vessels and enhance circulation and oxygen levels. Ginkgo Biloba extract also significantly increased telomerase activity.
Dr. Sears recommends taking 40mg -80mg for 4-6 weeks then stopping for 4-6 weeks, then starting up again. If you take Ginkgo Biloba continuously it loses it’s effectiveness.
Folic Acid
Stimulates the activation of telomerase.
  • Food sources include
  • Black eyed peas
  • Lentils
  • Spinach (raw)
  • Asparagus
  • Lettuce
  • Avocade
  • Broccoli
  • Tropical Fruits
  • Oranges
  • Wheat Bread

Acetyl L-Carnitine

This amino acid is a brain booster as well as an activator of the human telomerase gene.
  • Food sources include
  • Beef steak
  • Ground Beef
  • Pork
  • Bacon.

There you have it, some simple ways to boost your telomerase activity.

I don’t believe you need to run out and buy all the supplements. My advice is to be more conscious of the telomere boosting foods and include them more often in your diet.

The Most Important Test Your Doctor Won’t Order

By Al Sears MD

I’ve been getting a lot of mail from readers asking a similar question. Most are like this one from MK in Philadelphia: “I’m going for an annual checkup with my doctor soon. I want to make sure I’m getting the right tests. What’s the number one anti-aging test I should ask my doctor for?”
It’s a great question. The problem is your local doctor has probably never even heard of the top anti-aging test I recommend.
You see, I want to know what’s going on with you at the cellular level. And that’s why I think it’s essential to measure your telomeres.
Telomeres are an important part of human cells that affect how our cells age.
You know by now telomeres are the protective caps at the end of each strand of DNA. When you are young your telomeres are long. But every time a cell divides the telomeres get shorter.
Over time, your telomeres get so short they can’t protect your DNA as well. When a cell divides, new cells are defective. You begin to develop the signs and diseases of old age.
Short telomeres dramatically boost your risk of serious diseases. They’ve been linked to a 300% increased rate of death from heart disease. They’re also linked to an 800% higher death rate from infectious diseases.1
By measuring your telomeres, I can tell your true “biological age.” Telomere length is the strongest indicator of how quickly you’re aging and how old you really are.
So let’s say you’re tested when you’re 60 years old. It takes four to six weeks to get the results. I might see from your test results that you have a biological age of someone who’s 64. In other words, you’re aging faster than you should be.
One thing I would do right away is give you a plan to turn on telomerase.
If you’re a regular reader, you know telomerase is the enzyme that rebuilds your telomeres. When you turn it on, your telomeres gradually get longer. It slows down your aging. Your body starts creating younger and younger cells.
The next time I test your telomeres, they should be longer. I can show you on a graph how much younger your biological age is.
I use a telomere test from a company called Life Length. Their Telomere Analysis Technology (TAT) was developed by Dr. Maria Blasco, one of the leading telomere researchers in the world.
TAT is the best telomere test on the market. And it’s been proven accurate in clinical studies.2
Most labs can only measure “average telomere length.” Average length is good to know, but it’s not the whole story.
You see, each cell in your body has 92 telomeres. Some may have a healthy length. Others may be in trouble. Only the TAT test tells you how many “critically short” telomeres you have.
“Critically short” means that 70% to 80% of the telomere has already eroded away.
Those are the ones that can cause permanent cell damage.
When telomeres become critically short they activate the p53 gene. That gene gives the signal for the cell to go into emergency shutdown. The cell stops growing or dividing. Energy production plummets. Antioxidant activity drops. Free radicals attack and more telomeres become critically short.
As Harvard researchers explained, critically short telomeres can set in motion a “death spiral.”3
That’s why it’s so important to get a handle on the length of your telomeres. By getting your telomere length tested, you can be in control of your health and your life.
When I tested a group of my own patients, their average biological age was 58 years old. Then I put them on a protocol designed to activate their telomerase enzyme.
After 30 months the average age of the group dropped 14 years to 44 years old. I’ve seen some individuals reverse their biological age by 20 to 30 years!
If you would like to have your telomere length tested here at my Sears Institute for Anti-Aging Medicine in South Florida, please call us at 561-784-7852 and make an appointment today.
Even if you can’t get your telomeres tested, you can still protect them. Poor diet, lack of exercise, or stress can all accelerate wear and tear on your countdown clocks.
In as little as a year you can modify the length of your telomeres with some simple changes to your routine.
Here’s what you can do right now to activate telomerase and grow your telomeres.
  1. Eat More Fruits and Vegetables. Diets lower in refined carbohydrates and higher in fresh fruits and vegetables are linked to longer telomeres.
    Eating more magnesium-rich foods like leafy greens is linked to longer telomeres. The magnesium preserves and repairs DNA. Boost your magnesium levels by eating more kale, spinach, Swiss chard and seaweed. Other good choices include quinoa, lentils, almonds, sesame seeds, avocado, spirulina, and dark chocolate.
  2. Exercise. Studies show people who do little or no exercise have the highest risk of short telomeres. A study of 2,401 twins found vigorous exercise can lead to telomeres that act nine years younger.
    My PACE exercise program is the only system that specifically addresses the challenges of aging. It lets you get just the right amount of exertion to give you anti-aging benefits. And it takes as little as 12 minutes per day.
  3. Reduce Your Stress. I often recommend meditation to my patients. It’s one of the best ways to reduce stress. And it can also turn on telomerase activity. In one study of 39 caregivers, half listened to “relaxation” music. The other half practiced meditation for just 12 minutes a day. After only eight weeks, telomerase activity in the meditation group jumped 43%. The relaxation group went up a measly 3.7%.
  4. Raise Your HDL Levels. One of the best ways to maintain your telomeres is simply raise your HDL cholesterol as high as you can. In one study, people with the highest HDL had the longest telomeres.
    An easy way to raise your HDL is to take a special form of vitamin E called tocotrienols. Vitamin E is actually a group of eight nutrients, four tocopherols, and four tocotrienols. Studies show that tocotrienols give your HDL a huge boost. Look for a tocotrienol supplement with as much gamma and delta tocotrienols as you can.
  5. Boost Your Folic Acid. Folate or folic acid is one of the B vitamins. Studies show men with the highest folic acid levels have longer telomeres than those with low folate.
    Folate works by counteracting the effects of the amino acid homocysteine. High levels of homocysteine in your blood can triple the speed at which your telomeres shorten.
    I recommend getting 800 mcg of folic acid every day for your telomeres. Calf’s liver is one of the richest sources with 215 mcg in just three ounces. Dairy, poultry, meat, eggs, and seafood are other good choices. Among vegetables, dark leafy greens are a good source. Try spinach, broccoli, asparagus and Brussels sprouts.
    You can also take a folic acid supplement. But don’t overdo it. Too much folic acid can hide the symptoms of a vitamin B12 deficiency.
  6. Take a Potent Antioxidant. Raising the level of vitamin C in your cells could slow down the shortening of telomeres up to 62%.One study showed that vitamin C also stimulated telomerase activity in the formation and regeneration of stem cells.
    To help reverse aging, I recommend taking 5,000 mg to 8,000 mg every day. Be sure to divide that amount into multiple smaller doses throughout the day.
For more information, call the Sears Institute for Anti-Aging Medicine at 561-784-7852 or visit www.searsinstitute.com.
To Your Good Health,
Al Sears, MD, CNS
1Cawthon, R.M., Smith, K.R., O’Brien, E., et al, “Association between telomere length in blood and mortality in people aged 60 years or older,” Lancet 2003, 361(9355):393-395.
2Canela A, Vera E, Klatt P, Blasco MA. “High-throughput telomere length quantification by FISH and its application to human population studies.” Proc Natl Acad Sci U S A. 2007;104(13):5300-5.
3Sahin E, Colla S, Liesa M et al. “Telomere dysfunction induces metabolic and mitochondrial compromise.” Nature 2011;470:359-65.
4Mirabello L et al. “The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer.” Aging Cell. 2009;8:405–413
5Xu Q, Parks CG, DeRoo LA, Cawthon RM, Sandler DP, Chen H. “Multivitamin use and telomere length in women.” Am J Clin Nutr. 2009;89:1857–1863
6Krauss J, Farzaneh-Far R, Puterman E, Na B, Lin J, Epel E, Blackburn E, Whooley M. “Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study.” PLoS One. 2011;6(11):e26983.
7Cherkas L, Hunkin J, Kato B, Richards J, et al. “The association between physical activity in leisure time and leukocyte telomere length.” Arch Intern Med. 2008;168(2):154-8.
8Lavretsky H, Blackburn E, Irwin M, et. al. “A pilot study of yogic meditation … effects on mental health, cognition, and telomerase activity.” Int J Geriatr Psychiatry. 2013;28(1):57-65.
9Dei Cas A. et. al. “…cardiovascular disease and reduced HDL-cholesterol levels are associated with shorter leukocyte telomere length…” Nutr Metab Cardiovasc Dis. 2013;23(3):272-8.
10Hunninghake, et al, “Incorporation of lean red meat into a National Cholesterol Education Program Step I Diet,” Journal of the American College of Nutrition 2000;19(3):351-360.
11Paul L et al, “Telomere length in peripheral blood mononuclear cells is associated with folate status in men.” J Nutr. 2009;139(7):1273-8.
12Richards J et al. “Homocysteine levels and leukocyte telomere length.” Atherosclerosis. 2008;200(2):271-7.
14Furumoto K. et al. “Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress.” Life Science 1998, vol. 63, no. 11 pp. 935-48.
15Wei, F. “Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity.” J. Cell Physiol. Sept. 2012; 227 (9): 3216-24.

What Is Stem Cell Cancer's Killer? (HINT: It Costs $1)

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Dr. Sears Newest Product Launch: The Awful Truth About Turmeric

The awful truth

Whether you’re taking a turmeric supplement or
just considering it,
you need to see my shocking findings.

A discovery that could mean the difference between
getting ALL or NONE of turmeric’s proven health benefits.

Dear Health Conscious Reader,
You know I’ve touted the healing benefits of turmeric — and specifically its active ingredient curcumin — for years.

Long before it became a fad, I’ve talked about how it’s more powerful than Big Pharma’s synthetic chemicals… without the side effects.
But get this:
Here at the Sears Institute for Anti-Aging Medicine, we do NOT use typical turmeric supplements.
You see, in spite of all of turmeric’s health benefits, scientists have established that it has one drawback:
It’s very difficult for our bodies to absorb.
Three specific things are needed to solve that:
  • The right kind of curcumin, specifically three of the most powerful curcuminoids, at the right dose: 1000 mg per day

  • A proven delivery mechanism, shown by studies to get curcumin to your cells

  • And, perhaps most important all, similar ancient roots that MAGNIFY curcumin’s power.

These are all things that most so-called “turmeric” supplements are lacking…
And the result is…
They do NOT metabolize in your body…
They do NOT get to your cells where it’s needed most…
And they do NOT cross your blood-brain barrier.
The sad truth: most turmeric users only get LESS THAN 5% of its true healing potential.
Isn’t it outrageous that even with the mountain of scientific research proving its benefits… we still lack access to a TRUE source of something so powerful — and so proven — as turmeric?
I thought so.
That’s why I tasked my research team with the challenge of forming the world’s best, most absorbable kind of turmeric…
Adding similar roots and herbs that synergistically work with turmeric.
And combining it with the right technology that delivers its maximum healing potential…
A special “delivery system” that transforms turmeric from a kitchen spice into the world’s most powerful healer.
After over 12 months of preparation, I believe we’ve formulated…
The Biggest Turmeric Breakthrough
in 4,000 YEARS OF USE
And in just a moment, you’ll see why this is several generations ahead of conventional turmeric.
You’ll also discover…
  • How my patients are already seeing benefits you can’t get with most turmeric supplements.
  • 3 other natural roots I added that are proven to AMPLIFY turmeric’s strength.
  • And how you too can begin to experience the TRUE potential of turmeric, for the first time ever.

I traveled the world to find three natural roots with outstanding health benefits.
I’ll reveal all of this, and more, in just a moment.
But before I do, allow me to share with you what turmeric can REALLY do…
In fact, it delivers no less than 619 Essential Benefits for just about everything you can imagine.
Turmeric Delivers Over 619 Known Health Benefits
In a number of clinical trials, the results have been nothing short of remarkable.

In fact, just a handful of studies prove it…

checkmarkReverses memory loss from late-stage Alzheimer's in just three months — Journal of Alzheimer's Research and Therapy
Kills cancer stem cells (“the root cause of cancer”) —Journal of Anticancer Research
Shrinks tumors with 81% success rate — Journal of Nutritional Biochemistry
Destroys more colon cancer stem cells than Adrucil (one of the most widely prescribed chemotherapy drugs - Baylor University researchers.

Clinical Trials Prove Turmeric is More Powerful than The Popular Treatments in your Medicine Cabinet — Without Side Effects
Proof: In a study published in the journalMolecular Nutrition and Food Research, animals were given curcumin and a popular cholesterol solution over 18 weeks. The curcumin did better at supporting healthy cholesterol levels and gave no side effects.15
Proof: Published in the Journal of Clinical Interventions of Aging, knee joint patients were given either a popular joint treatment or curcumin. Over the course of six weeks, both groups saw the exact same support of healthy joints, but there was one difference: the curcumin group saw zero side effects. 16
Proof: In a study published in theInternational Journal of Impotence, researchers treated animals in three group: curcumin; a best-selling erectile solution; and a combination of the two. They found the curcumin group and the combination group “could enhance erectile function with more efficacy and more prolonged duration of action.” 17
Proof: Researchers treated patients with vision problems using curcumin in one group and a popular eyesight therapy in the other. In three months, 100% of patients taking curcumin saw healthy middle layers of eyeball tissue. The other group only saw 86% success. What’s more, a follow-up done three years later found the curcumin group had greater long-term eye health support, and with no side effects.18
Proof: In the journal Phytotherapy Research, researchers split up patients into three groups, giving one curcumin; one a popular mood booster; and the other a combination of the two. In the span of six weeks, curcumin and the popular mood booster worked equally well, but the combination of the two did better with fewer side effects. 19
Proof: Auburn University researchers compared curcumin to a popular blood sugar solution in their ability to balance glucose levels. They found curcumin was a stunning 10,000 times more powerful at supporting healthy glucose, and with no side effects.20
The list goes on and on.
This is just a small sample of what turmeric can do for you better — and safer — than anything else…
These are the sort of life-changing results my patients and I are now used to seeing all of the time.
But it’s only possible IF the turmeric is actually absorbable… and IF it crosses the blood-brain barrier.
Which is why I’ve added a new technology that’s proven to achieve both those things.
Something that a study at St. John’s University found enhances the power of turmeric by 2,000%.21
New Technology Enhances Turmeric’s Power
by 2,000%
Researchers there compared blood levels of curcumin alone vs. combining it with bioperine…
And within 45 minutes of use, patients saw a stunning 2,000% increase in curcumin levels.
Not only that, lasted longer in the bloodstream.
Now research is confirming that it actually WORKS better, too.
Special Technology Helps Curcumin
Better Support Healthy Cholesterol
and Triglyceride Levels
In one study, researchers took healthy animals, split them into three groups, and fed them a high-fat diet.22
In addition, group 2 received curcumin and group 3 received curcumin and piperine. And the results were breathtaking…
In over four weeks, the group that received curcumin and piperine saw NO changes to their blood levels.
In other words, the effects of a high-fat diet on their cholesterol and triglyceride levels were negligible.
In fact, their HDL (“good”) cholesterol levels actually increased!
That’s what curcumin is SUPPOSED to do. And piperine helps it get those results.
Enhances Mood, Happiness and Positive Attitude
In another study, researchers treated melancholic animals with curcumin or a combination with piperine.23
They found that the curcumin/piperine significantly boosted the subject’s dopamine and serotonin levels, which are essential to mood and happiness.
The study concludes,
“Curcumin along with piperine may prove to be a useful and potent natural approach in the management of mood.”
Superior at Maintaining Healthy
Blood Sugar Levels
In another study, researchers treated animals in three groups: 1) curcumin alone 2) a standard blood sugar solution or 3) curcumin and piperine. 24
One month later, they analyzed the glucose levels and saw better results in the curcumin/piperine group compared to the other groups!
The curcumin/piperine group also saw…
  • Better support for healthy LDL cholesterol and triglycerides
  • Better support for healthy weight levels
  • And support for healthy glucose levels
And that’s just for starters…
A series of global studies are finding that curcumin and piperine together work better than curcumin alone to shield your mind and body from oxidative stress 25and neurotoxicity 26, and helps support healthy DNA. 27
All of which are shown to wreak havoc your health.
The research is clear:
This “bioperine” delivery system makes the difference between getting only a fraction of curcumin’s potential…

Or the full spectrum of its true healing benefit. And that means serious results like…
  • A longer, healthier life;
  • “Sharp-as-a-tack” thinking and memory recollection;
  • Easy, comfortable, pain-free mobility;
  • Crystal-clear eyesight;
  • A happier, calmer mindset — free from stress, anxiety and worry;
  • Healthy blood sugar levels;
  • Healthy cholesterol and triglyceride levels;
  • Easy, smooth, hassle-free digestion;
  • Healthy kidneys, liver and lungs;
  • A slim, fit figure;
  • A healthy, ageless heart;
  • And much, much more.
You don’t enjoy results like these unless you have a proven delivery system for turmeric.
That’s why I refused to make a curcumin formula without including one, like so many supplement makers have.herbs
But I took it a step further.
Two steps further, to be exact.
I’ve added two spices that belong to the curcumin “family”.
They’re both members of the elite group of rhizomes (root-like underground stems).
They’re both staples of ancient Ayurvedic medicine that go back over 4,000 years, just like curcumin.
And they both have similar proven benefits as curcumin, and act on age-related inflammation in a similar way.
So when all three are added together, they not only complement, but magnify curcumin’s results.
These are just a few reasons why I’ve made them key to my new formulaCurcumin Triple Burn.
Let me tell you a little bit about each right now… and why they make curcumin even more powerful…
Curcumin Amplifier #2:

Sacred Texts Call it “The Spice from Heaven”

The first is perhaps the world’s oldest medicinal spice, used going back 5,000 years at least.
It was first grown in Ancient China and India, where it was touted as a gift from God.
Then it spread all around the world as a luxury and powerful form of medicine.
In fact, ancient texts going back to the earliest Sanskrit literature praise it as an all-purpose healer.
So do medicinal books in ancient Rome, Greece and the Middle East.
The Quran calls it a “spice from heaven.”
Most of the prescriptions written in Chinese traditional medicine included a combination of herbs.
And this one was in over half of them!
Explorer Marco Polo thoroughly documented its cultivation and use in his expedition to East Asia.
The Roman Empire considered it a luxury reserved for the rich.
And it was very expensive: one pound of this spice was equivalent to a whole sheep or cow.
But not the kind in your spice cabinet, cookies or soda. Nor just any plain ol’ ginger supplement.I’m talking about ginger, of course.
Instead, I recommend a concentrated dose of its most powerful medicinal compound: gingerol.
Just like curcumin is the molecular “hero” in turmeric, so too is gingerol the powerhouse inside ginger.
And now scientists are finding that the ancients were more right than you could imagine. Some of its benefits include…
  • Nausea relief 28
  • Fast metabolism and healthy weight levels 29
  • Healthy blood flow and circulation
  • Smooth, comfortable joints 30
  • Healthy blood pressure levels 31
  • Healthy cholesterol and triglyceride levels 32
  • Smooth, hassle-free digestion
  • Healthy blood sugar levels 33
  • Improved insulin support 34
That’s why I call ginger “nature’s multi-tool.” There’s not much it can’t do or help. And now we know why…
You see, ginger “switches off” the genes that cause age-related inflammation — much like curcumin.
The most powerful of these is the molecule Nuclear Factor-kappa beta (NF-kB) — the body’s inflammation command center.
Shuts Down Our Body’s “Inflammation Command Center”
NF-kB is the “switch” that activates over 400 of our body’s pro-inflammatory genes. Including the enzymes COX-2, iNOS and LOX.
As a result it provides our body the blueprint for regulating its inflammatory response.
Big Pharma considers it the “Holy Grail” for age-related inflammation. But they’ve failed to reliably and safely target it using drugs. 35
That’s okay.
Because nature already designed at least two powerful NF-kB deactivators: curcumin and ginger.
Curcumin’s effects on NF-kB are renowned. But it’s hardly known that ginger does the exact same thing. 36
In combination they’re a powerful duo against the leading cause of age-related inflammation.
That’s also why studies point to ginger as such a powerful joint remedy.
One double-blind study treated 120 joint patients with either a placebo or gingerol.
In just 12 weeks, the ginger group saw remarkably healthy inflammation markers.
The researchers conclude it’s because the gingerol extract deactivated the NF-kB gene. 37
The result: its joint-relief benefits are second to none.
In fact, researchers at the University of Miami are now saying that ginger could be a first-line joint treatment. 38
In a double-blind study, they compared gingerol extract to a placebo in 261 knee joint patients.
They found the ginger supported healthy joint comfort by 40 percent over the placebo… in just six weeks.
“Research shows that ginger affects certain inflammatory processes at a cellular level,” says the study’s lead author, Roy Altman, MD. 39
What makes ginger so powerful?
Most joint solutions simply block the formation of certain inflammatory compounds.
Ginger, on the other hand, not only “turns off” the master commander of age-related inflammation…
But also has antioxidant effects that break down existing inflammation and acidity in the fluid within the joints.
That’s why the researchers concluded that its work superior to popular joint treatments.
“Ginger has anti-inflammatory… and antioxidant activities, as well as a small amount of [pain relieving] property,” says Roberta Lee, MD, vice chair of the Department of Integrative Medicine at Beth Israel Medical Center.
But ginger didn’t deliver these results alone.
In fact, there was another spice used in the study that went overlooked.
Curcumin’s other, lesser-known relative.
It’s the third member of the elite group of rhizome plants.
In combination with ginger, the research shows it works wonders on a variety of health concerns.
Like curcumin and ginger, it has a 4,000-year history of use in ancient medicine systems.
So it was a no-brainer as my third curcumin amplifier.
Curcumin Amplifier #3:
“The Spice of Life”
It’s called galangal.
Just like ginger, galangal warms the body and aids in digestion. It’s also a powerful anti-nausea remedy.
Of course, it also shows similar antioxidant, anti-inflammatory and antimicrobial powers. 40
Since it doesn’t have the same recognition as either curcumin or ginger, it hasn’t been studied so extensively.
But researchers are already calling it “the gold mine of future therapeutics.41
It was not until the 800s AD that galangal found its way in to European hands through spice trade with the East.
The famed St. Hildegard, a renowned healer and expert in herbal medicine, recognized galangal’s powers and dubbed it the “Spice of Life.”
A cure-all for many conditions that ravaged Europe at the time.
In fact, amidst the Bubonic Plague that destroyed a third of Europe’s population, people created potential life-saving medicines.
Medicines that included galangal due to its antimicrobrial properties.
One of the most famous legends was that of the “Four Thieves” — four men who went around sacking the homes of plague victims, but never contracted the plague.
Their immunity was credited to the “Four Thieves Oil” they designed, which included galangal.
That’s just a few reasons why I’ve made galangal one of the key ingredients of my new breakthrough.
Again, I call it Curcumin Triple Burn.
The “Next Generation” of Curcumin is Here
In all my years on the cutting edge of natural health, I’ve never seen a curcumin formula like it. None that include a therapeutic dose of curcuminoids… delivery technology proven to enhance its absorption by 2,000%… or spices that complement and amplify curcumin’s healing potential.
But that’s not all.
I’ve added one more extra “kicker” to boost this formula’s results.
Bonus Curcumin Amplifier
This final ingredient belongs to an elite class of herbs called “adaptogens.”
And just as the name sounds, it adapts to what your body needs, at any given moment.
Need sleep? Energy? Stamina? Stress relief?
These herbs are so smart, and so powerful, they deliver it you. And the effects last all day long.
Adaptogens recently started gaining ground in America, but in India, Russia and China they’ve been a staple form of medicine for thousands of years.
Over 25 herbs are classified as adaptogens. One in particular is being recognized as a leader in Ayurvedic medicine.
And I’ve made this “smart herb” the platoon leader of my curcumin formula.
So while the curcumin, the two other spices, and the delivery system are the elite soldiers…
This herb harnesses their full healing potential… commands exactly where they target… and keeps them disciplined, working all throughout the day, in any situation, for whatever your body needs.
Its scientific name is Ocimum Sanctum. It’s better known as Holy Basil, or “Tulsi.”
Within Ayurveda, Holy Basil is known as “The Incomparable One,” “Mother Medicine of Nature,” and “The Queen of Herbs.”
And it’s revered as an “elixir of life” without equal in its healing powers, which are now being confirmed by modern science.
One group of scientists that reviewed all of the studies conducted on Holy Basil even called it…
“The Wonder Herb” 42
Another group of researchers call it an “herb for all reasons.” 43 And it’s not hard to see why.
The World’s Ultimate Stress-Buster
Tulsi – just like other adaptogens – is proven to balance serum levels of cortisol.44 And that’s no small matter.
The so-called “stress hormone” is proven to wreak havoc on your mind and body.
Psychology Today is even calling cortisol “Public Enemy No. 1.” 45
And now we know why it’s so dangerous…
You see, it was previously thought cortisol overload simply broke down our immune system… causing colds.
According to groundbreaking new research at Carnegie Mellon University, high levels of cortisol – caused by chronic stress – decrease the sensitivity of our immune cells to hormone signaling.But it’s not so simple.
The illness that results is simply the “side effect” of the runaway inflammation. 46This triggers the immune system’s cytokine cells to release a non-stop inflammatory response.
Perhaps that’s why stress has been implicated in just about every health concern imaginable.
And why Holy Basil – a proven cortisol regulator – is proven to work on so many age-related conditions.
Take one study done on blood sugar patients. 47
Half of the patients were given 2.5 g of holy basil leaf powder daily, and the other half were given a placebo for four weeks.
Compared to the control group, the group administered holy basil experienced some amazing results.
Not only did fasting glucose and post-meal glucose reach normal healthy levels. They saw enhanced support for healthy cholesterol levels during the treatment as well!
In another study, holy basil extract (500 mg twice daily) enhanced mood in unhappy middle-aged adults.
It also improved the “willingness to adjust” to circumstances beyond their control – a key factor in stress-induced sadness. 48
And it’s a powerful brain booster, too – much like curcumin.
In a human study, researchers found that 300 mg a day of holy basil leaf extract produced a significant improvement in many different cognitive parameters, including reaction time and error rates on standardized tests, as well as on a test that measures anxiety. 49
This is the final ingredient in my new curcumin breakthrough formula: Curcumin Triple Burn.
Amazing: What You Get in Every Single Pill
With every single dose of Curcumin Triple Burn you get…
At last! The full power of turmeric unleashed…
And for LESS THAN $1
Nothing quite has health-concerned individuals so excited as turmeric. And for good reason…
It seems like every day the new science shows its healing potential is second to none.
There’s almost nothing it can’t do for your body… no result it can’t deliver… and no health concern it doesn’t address.
That’s why I’ve gone above and beyond to not only release turmeric’s MAXIMUM potential…
But to make it even more affordable, and accessible to YOU.
As you may know, I’ve referred to curcumin as the $1 pill. And that’s certainly true, at least for most formulas.
Yet even with everything I’ve added to this formula…
Even with the complementary herbs…
Even with the 2,000% boosting technology… and the adaptogen to harness its full potential…
On top of a therapeutic 1,000 mg dose of the three most powerful curcuminoids…
I’m going to do better than $1 for you.
The 70-Cent Pill for Everything
If you select the three-month, Auto Delivery option – you can lock in this curcumin breakthrough for just 70 cents a day. So please, don’t delay. I really want you to take advantage of my offer right now. That’s just 35 cents per pill.
I want you to start enjoying every benefit turmeric has to offer…
I want you to experience its unparalleled 619 proven health benefits…
I want you to start feeling younger brain power, energy and vitality.
So don’t wait any longer. Click here to order.
To Your Good Health,
Al Sears, MD, CNS

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2 Chuengsamarn S, et al. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012 Nov ;35(11):2121-7.
3 Akazawa N, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct ;32(10):795-9.
4 Yang YS. Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res 2014 Dec;28(12):1770-7.
5 Chandrashekara KT, et al, “Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster,” Age, vol. 36, no. 5, 2014
6 Belcaro G, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Alternative Medicine Review 2010 Dec;15(4):337-44.
Thring et al. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complement Altern Med 2009, 9:27 doi:10.1186/1472-6882-9-27.
YBundy R, Walker AF, Middleton RW, Booth J. “Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study.” Journal of Alternative & Complementary Medicine. 10(6):1015-8, 2004
McFarlin BK, Venable AS, Henning AL, Best Sampson JN, Pennel K, Vingren JL, Hill DW. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clinical 2016; 5:72-78.
Lal B, Kapoor AK, Asthana OP. Efficacy of curcumin in the management of chronic anterior uveitis.Phytother Res. 1999 Jun;13(4):318-22.
11 Xiao Z, Zhang A, Lin J, Zheng Z, Shi X, Di W, et al. (2014) Telomerase: A Target for Therapeutic Effects of Curcumin and a Curcumin Derivative in Aβ1-42 Insult In Vitro. PLoS ONE 9(7).
12 “Curcumin May Prevent Clogged Arteries.” WebMd.com, 20 July 2009.
Khajehdehi P. Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study. J Ren Nutr. 2012 Jan;22(1):50-7.
Wanwarang W, et al. Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. Am J Cardiol. 2012 Jul 1 ;110(1):40-4.
Kuptniratsaikul V, et al. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med. 2009;15(8):891-897.
16 Shin SK, HA TY, McGregor RA, Choi MS. Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Mol Nutr Food Res. 2011 Nov 7.
Zaahkouk AMS, et al, “Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function,” International Journal Of Impotence Research, vol. 27, no. 1, pp. 9–15, 2015.
Lal B et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother Res 1999 Jun;13(4):318-22.
19 Sanmukhani J, et al. Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial. Phytother Res. 2013 Jul 6.
20 Kim, T., Davis, J., Zhang, A.J., He, X., and Mathews, S.T. (2009) Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biophys. Res. Commun. 388, 377–382.
21 Shoba G, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.
22 Tu, Y, et al. Piperine potentiates the hypocholesterolemic effect of curcumin in rats fed on a high fat diet. Exp Ther Med. 2014 Jul;8(1):260-266.
23 Bhutani MK, et al. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol Biochem Behav. 2009 Mar;92(1):39-43.
24 Kaur G, et al. Influence of Piperine and Quercetin on Antidiabetic Potential of Curcumin. J Complement Integr Med. 2016 Jun 25.
25 Panahi Y, et al. Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial. J Diet Suppl. 2016;13(1):93-105.
26 Singh S, et al. Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism. Neurochem Res. 2015 Aug;40(8):1758-66.
27 Sehgal A, et al. Combined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damage. Food Chem Toxicol. 2011 Nov;49(11):3002-6.
28 Ryan JL, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012 Jul;20(7):1479-89.
29 Mansour MS, et al. Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study. Metabolism. 2012 Oct;61(10):1347-52.
30 Altman RD, et al. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001 Nov;44(11):2531-8.
31 Akinyemi AJ, et al. Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats.Phytother Res. 2016 Jul;30(7):1156-63.
32 Tahereh A, et al. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int J Food Sci Nutr. 2014.
33 Ibid.
34 Ibid.
35 Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009 Dec;1(6).
36 Lee HY, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol. 2012 Sep;167(1):128-40.
37 Naderi Z, et al. Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial. J Tradit Complement Med. 2015 Jan 28;6(3):199-203.
38 Altman RD, et al.
39 “Health Benefits of Ginger.” Arthritis Today Magazine, 22 Jan. 2016.
40 Altman RD, et al.
41 Ghosh, S. Alpinia: the gold mine of future therapeutics. 3 Biotech. 2013 Jun; 3(3): 173–185.
Sai Krishna. G., et al. “Tulsi” – the Wonder Herb (Pharmacological Activities of Ocimum Sanctum).American Journal of Ethnomedicine, 2014, Vol. 1, No. 1, 089-095
43 Cohen MM, et al. Tulsi – Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med. 2014 Oct-Dec; 5(4): 251–259.
44 Jothie Richard E, Illuri R, Bethapudi B, et al. Anti-stress activity of Ocimum sanctum: Possible effects on hypothalamic-pituitary-adrenal axis. Phytother Res. 2016;30(5):805-14.

45 “Cortisol: Why the Stress Hormone is Public Enemy No. 1.” Psychology Today, 22 Jan. 2013.
46 Cohen, S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk.PNAS, April 2, 2012
47 Agrawal P, et al. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther. 1996 Sep;34(9):406-9.
48 Bhattacharyya D, Sur TK, Jana U, et al. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J. 2008;10(3):176-9.
49 Sampath S, Mahapatra SC, Padhi MM, et al. Holy basil (Ocimum sanctum Linn.) leaf extract enhances specific cognitive parameters in healthy adult volunteers: A placebo controlled study. Indian J Physiol Pharmacol. 2015;59(1):69-77.