FEATURED POST

Telomere - Wikipedia

Google: lengthen telomeres naturally Telomere - Wikipedia Telomeres are repetitive nucleotide sequences located at the termini of l...

Cracking the telomere code: The first step to reverse aging

4th International Conference on Tissue Science and Regenerative Medicine


July 27-29, 2015 Rome, Italy

 Al Sears

Scientific Tracks AbstractsJ Tissue Sci Eng

Abstract :

This lecture explores the discovery of the telomerase enzyme and its role as a crucial indicator of health and longevity. By tracing the evolution of telomere research, including the landmark Harvard study that fully restored youthful function in mice by activating the telomerase enzyme, Dr. Sears unveils the true age-reversing, and health-transforming potential of telomere therapy and the capacity to influence gene expression through novel interventions. As one of the only medical doctors to administer the world?s first telomere therapy, Dr. Sears relates its effects on his own patients, and how his own research uncovered new, more effective ways of supporting telomere length and altering telomere biology. Three learner objectives. By the end of the lecture, participants will understand: ? The evidence that supports the telomere?s role as the true cause of aging. ? What factors cause the telomere to shorten, and the most reliable interventions to support telomere length. ? How the search for telomerase activators uncovered new, more powerful and more affordable means of affecting telomere regulation.

Biography :

Al Sears, M.D. is the founder of the Center for Health and Wellness, a successful integrative medicine and anti-aging facility in Royal Palm Beach, Florida, with over 25,000 patients. His cutting-edge therapies and reputation for solving some of the most difficult-to-diagnose cases attract patients from around the world. Sears was one of the first to be board-certified in anti-aging medicine. As a pioneer in this new field of medicine, he is an avid researcher, published author, and enthusiastic lecturer.Sears is board-certified as a clinical nutrition specialist and a member of the American College of Sports Medicine (ACSM), the American College for the Advancement in Medicine (ACAM), the American Medical Association (AMA), the Southern Medical Association (SMA), the American Academy of Anti-Aging Medicine (A4M), and the Herb Research Foundation, (HRF). Dr. Sears is also an ACE-certified fitness trainer.Sears currently writes and publishes the monthly e-Newsletter, Health Confidential, and daily email broadcast, Doctor?s House Call, and contributes to a host of other publications in the field. He has appeared on over 50 national radio programs, ABC News, CNN, and ESPN.Since 1999, Dr. Sears has published 15 books and reports on health and wellness with a readership of millions spread over 163 countries.


Download The PDF. Here

Tru Niagen Chromadex May Protect Telomeres

New preclinical study finds boosting NAD+ with nicotinamide riboside alleviated telomere damage, providing protective effect to DNA strands

LOS ANGELES--(BUSINESS WIRE)-- ChromaDex Corp. (NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. This study is the first to show that by increasing NAD+, NR helped protect telomeres which are important in addressing life-threatening telomere-related diseases, paving the way for future clinical research. The study was conducted by investigators at the National Institute on Aging (NIA) and the National Cancer Institute (NCI), parts of the National Institutes of Health (NIH). The role of ChromaDex in this study was to provide NR through the ChromaDex External Research Program (CERP). All other aspects of the study, including analysis of the results and writing of the manuscript were conducted independently by the authors.

“Telomere attrition is recognized as one of the nine hallmarks of aging and it is well accepted that telomeres play a significant role in aging and many age-related health declines,” said Frank Jaksch, Co-Founder & Executive Chairman of ChromaDex. “These preliminary results suggest that NR can impact telomere function.”

Telomeres are “caps” at the end of chromosomes that protect DNA from getting worn away as cells replicate. Telomeres degrade and shorten with age and can become excessively damaged in certain genetic diseases, as well as from lifestyle factors such as smoking, poor diet, and chronic stress. Shortening of telomeres is associated with the symptoms of aging, heart disease, DNA damage and uncontrolled cell replication, which can lead to cancer.

Dyskeratosis congenita (DC) is a disease of pre-mature aging, which occurs due to a deficiency of telomere maintenance proteins. Without normal telomere function, DC presents with early-onset, life-threatening symptoms of aging in the skin, bone marrow, lungs, heart and brain.

In this recently published study, scientists examined connective tissue cells from DC patients and found that, not only were their telomeres significantly damaged, but they were also depleted in NAD+. Likewise, these scientists produced “telomere-depleted” mice by inactivating a gene for telomerase, the enzyme that extends telomeres. These mice also had low NAD+ levels.

The scientists then supplemented the cells and mice with NR. NR works by raising levels of NAD+, an important regulator that is known to naturally decline with age. In this study NR increased NAD+ levels, reduced signs of telomere damage, promoted cell growth and prevented senescence (cellular aging) in the DC cells.

These promising findings suggest that NAD+ repletion plays a role in maintaining healthy telomere function; however, additional research is needed.

While congenital telomere disorders like DC are rare, telomere dysfunction is implicated in signs and symptoms of normal human aging. Whether NR could play a role in supporting various aging organs is currently under investigation in dozens of human trials.

ChromaDex, the exclusive licensee of Dr. Charles Brenner’s patented NR, has invested over $35 million in investigating, manufacturing and offering NR in the form of Niagen and has secured more than 20 patents. ChromaDex has demonstrated the safety and efficacy of Niagen in 11 published human trials (and over 20 additional ongoing studies further evaluating its safety and efficacy) and has achieved government regulatory acceptance in the United States, Canada, the European Union, and Australia.

For additional information about ChromaDex, please visit www.chromadex.com.

About ChromaDex:

ChromaDex Corp. is a science-based integrated nutraceutical company devoted to improving the way people age. ChromaDex scientists partner with leading universities and research institutions worldwide to discover, develop and create solutions to deliver the full potential of NAD and its impact on human health. Its flagship ingredient, NIAGEN® nicotinamide riboside, sold directly to consumers as TRU NIAGEN®, is backed with clinical and scientific research, as well as extensive IP protection. TRU NIAGEN® is helping the world AGE BETTER®. ChromaDex maintains a website at www.chromadex.com to which ChromaDex regularly posts copies of its press releases as well as additional and financial information about the Company.

Forward-Looking Statements:

This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended, including statements related to whether NR helps improve telomere dysfunction and whether NAD+ repletion will play a role in maintaining healthy telomere function in humans. Statements that are not a description of historical facts constitute forward-looking statements and may often, but not always, be identified by the use of such words as "expects," "anticipates," "intends," "estimates," "plans," "potential," "possible," "probable," "believes," "seeks," "may," "will," "should," "could" or the negative of such terms or other similar expressions. More detailed information about ChromaDex and the risk factors that may affect the realization of forward-looking statements is set forth in ChromaDex's Annual Report on Form 10-K for the fiscal year ended December 31, 2019 as amended, ChromaDex's Quarterly Reports on Form 10-Q and other filings submitted by ChromaDex to the SEC, copies of which may be obtained from the SEC's website at www.sec.gov. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and actual results may differ materially from those suggested by these forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement and ChromaDex undertakes no obligation to revise or update this release to reflect events or circumstances after the date hereof.

ChromaDex Media Contact:
Alex Worsham, Senior Director of Global Corporate Communications
310-388-6706 ext. 689
alexw@chromadex.com

ChromaDex Investor Relations Contact:
Brianna Gerber, Vice President of FP&A and Investor Relations
949-419-0288 ext. 127
briannag@chromadex.com

Source: ChromaDex Corporation

First-Time Human Study Shows Reversal in Biology of Aging - Telomere Shortening and Senescent Cells Accumulation - with Hyperbaric Oxygen Therapy (HBOT)

NEWS PROVIDED BY

The Sagol Center for Hyperbaric Medicine and Research 

18 Nov, 2020, 16:11 IST


TEL AVIV, Israel, Nov. 18, 2020 /PRNewswire/ -- Tel Aviv University and The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center announced today that, for the first time in humans, two key biological hallmarks of aging, telomere length shortening and accumulation of senescent cells, can be reversed, according to a new study.

Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study, part of a comprehensive research program targeting aging as a reversible disease, is to be published in the peer-review journal Aging, and titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.

The biological deterioration of aging is cited as a major risk factor for cancer, cardiovascular diseases, diabetes, dementia and Alzheimer's disease.

At the cellular level, two key hallmarks of the aging process are:

  1. The shortening of telomere length, of approximately 20-40 bases per year, which is associated with a variety of serious life-threatening illnesses; and
  2. The accumulation of senescent cells, the so-called "old malfunctioning cells," which inhibit cell proliferation. The accumulation of senescence contributes to many age-associated conditions and illnesses, while elimination of those cells can reverse them, as shown in previous animal studies.   

The prospective clinical trial, part of a comprehensive aging research program taking place in Israel, was conducted by Prof. Efrati, MD, from  the Faculty of Medicine and Sagol School of Neuroscience at Tel Aviv University and Amir Hadanny, MD, Chief Medical Research Officer of The Sagol Center for Hyperbaric Medicine and Research and co-author of the study. It is the first study to evaluate whether HBOT can affect telomere length and senescence using a specific HBOT protocol. The trial included 35 healthy independent adults aged 64 and older who did not undergo any lifestyle, diet or medication adjustments. Each patient received 60 daily HBOT sessions over the course of 90 days. Whole blood samples were collected prior to treatment, at the 30th and 60th session, and one to two weeks following the last HBOT session, to assess peripheral blood mononuclear cells (PMBCs) telomere length and senescence. 

"After dedicating our HBOT research to exploring its impact on the areas of brain functionality and age related cognitive decline, we have now uncovered for the first time in humans HBOT's biological effects at the cellular level in healthy aging adults," said Prof. Shai Efrati. "Since telomere shortening is considered the 'Holy Grail' of the biology of aging, many pharmacological and environmental interventions are being extensively explored in the hopes of enabling telomere elongation. The significant improvement of telomere length shown during and after these unique HBOT protocols provides the scientific community with a new foundation of understanding that aging can, indeed, be targeted and reversed at the basic cellular-biological level."

Results found that the telomere length of T helper, T cytotoxic, natural killer and B cells increased significantly, by over 20 percent, following HBOT. The most significant change was in B cells, which increased at the 30th session, 60th session and post HBOT by 25.68%±40.42 (p=0.007), 29.39%±23.39 (p=0.0001) and 37.63%±52.73 (p=0.007), respectively. In addition, there was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT (P<0.0001). T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59 (p=0.0004) post-HBOT.

"Until now, interventions such as lifestyle modifications and intense exercise were shown to have some inhibition effect on the expected telomere length shortening. However, what is remarkable to note in our study, is that in just three months of HBOT, we were able to achieve such significant telomere elongation – at rates far beyond any of the current available interventions or lifestyle modifications," explained Dr. Hadanny. "With this pioneering study, we have opened a door for further research on the prolonged cellular impact of HBOT to reverse the aging process."

Professor Efrati, the research group leader, is a medical advisor to Aviv Scientific LTD, which has developed a comprehensive program that includes HBOT treatment, cognitive and physical training and nutritional coaching, to enhance brain and body performance of aging adults based on the Sagol HBOT protocol at Aviv Clinics. Prof. Efrati serves as Chair of Aviv Scientific's Medical Advisory Board.

Nechama Feuerstein
Finn Partners for The Sagol Center for Hyperbaric Medicine and Research
+1-551-444-0784
Nechama.feuerstein@finnpartners.com

SOURCE The Sagol Center for Hyperbaric Medicine and Research

Related Links

https://www.shamir.org/en/unique-pages-default-aspx/the-sagol-center-for-hyperbaric-medicine-and-research/

Anti-Aging Oxygen Therapy Protocol Reviewed


Molecular oxygen as a telomere supplement has the scientific community looking at this therapy to reverse the aging process in humans.  

(Source: Science News) (Hyperbaric Oxygen Treatment: Clinical Trial Reverses Two Biological Processes Associated With Aging In Human Cells

Date:
November 20, 2020
Source:
American Friends of Tel Aviv University
Summary:
A new study indicates that hyperbaric oxygen treatments (HBOT) in healthy aging adults can stop the aging of blood cells and reverse the aging process. In the biological sense, the adults' blood cells actually grow younger as the treatments progress.

(Source: Dr. Sircus

The researchers found that a unique protocol of treatments with high-pressure oxygen in a pressure chamber can reverse two major processes associated with aging and its illnesses: the shortening of telomeres (protective regions located at both ends of every chromosome) and the accumulation of old and malfunctioning cells in the body. Focusing on immune cells containing DNA obtained from the participants' blood, the study discovered a lengthening of up to 38% of the telomeres, as well as a decrease of up to 37% in the presence of senescent cells. 

There is nothing more basic to life than Oxygen. Oxygen is invincible in its ability to give or take away life and that goes as much for cancer cells as it does for healthy human cells. 

Oxygen can heal and it can kill so it is perfect for infections of all types. There is a way to increase the amount of Oxygen in the human body, practicing Oxygen Therapy. 

Oxygen Therapy introduces a new simple way of injecting massive amounts of oxygen into the cells. In fifteen minutes one can open the cells allowing them to detoxify as they gulp down higher levels of oxygen. What I have discovered will help many people pull out of chronic situations where they have not been able to do so before. 

Oxygen therapy is as wonderful as it is because more oxygen translates into more cellular energy, more healing energy and more energy to help us feel relaxed and perform better in life. Importantly enough when ample oxygen rushes into oxygen deficient cells oxygen is no longer the limiting reagent for detoxification of cellular poisons that have been accumulating. 

Increasing our oxygenation to tissues is one of the greatest influences on our bodily pH and the use of exercise with a MaxxO2 system will be recommended. One cannot stay physically present on earth forever but with enough oxygen eternal youth can be ours until our time is up!


Support Telomere Length

The results confirm and expand previous work on the genetics of telomere length, while acknowledging that the effect of lithium may be limited to a small number of cells in the human body, rather than the entire body. Although ageing is a complex process, we have found a clear - and well-defined - biomarker of ageing at the cellular level: the length of telomerase, the protective layer of the cell. While researchers are linking aging and disease, the breed is in the process of understanding the factors that determine the length of the teloreceptor. We note that our results provide the first direct evidence of the role of lithium in aging, which has been poorly understood at both cellular and molecular levels. Sources: 7, 9, 14, 16
In our study, current family and social support had a positive relationship with telomere length, but unsurprisingly not against the historical burden of childhood stress. However, this small study provides a good basis for recent research on the role of stress in the development of teloreceptors and the effects of lithium on telomerase. Alternatively, social support may play a protective role by buffering the effects of stress on telomere length, which shortens the rate of cell replication, and mitigating the negative effects of stress on telomeres. Sources: 5, 8
Understanding how telomere length is regulated is crucial to realizing the potential benefits of lithium in the development of teloreceptors and other cell types, "Rivera said. We focus on the role of stress and social support in supporting telitere structure and function in human health. Sources: 11, 14
On the surface, it seems desirable to strike a balance between maintaining and increasing telomere length and telomerase activity. Since telomeres can shorten in the context of aging and be maintained and prolonged by telomerase, it is logical that interventions modulating the telomerasing duo of teloreceptors represent a chance to prevent, delay, or minimize the degenerative diseases associated with age. Sources: 6, 11
However, it is unwise to say that increasing telomere length by pharmacological or nutraceutical means is advisable, as it can cause undesirable side effects. Sources: 6
Matt Kaeberlein, who studies the molecular basis of aging at the University of Washington, says: "By measuring telomere length in the blood, we are actually reporting a well-functioning immune stem cell. When we measure the length of a single cell, such as a blood stem cell, we need to think about how much work the stem cell does and how often it is supported by a particular tissue. Sources: 1, 2
Analysis of telomere structure, function and biology will be crucial to clarify the role of lithium in maintaining telomere length and structure. Vitamins C and E can limit the effects of the shortening of telotechnologies, such as those found in blood stem cells, on short- and long-term telomeres. On the other hand, the critical telomerase length can lead to a fusion of the chromosomes by the NHEJ mechanism or to the telomeres uncapping. Future longitudinal studies to assess the effect of lithium on age - the associated disease risk is likely to be based on confirmation that gene transcripts are the primary mediator in lithium tele - will prolong the effects on teloneurons. Sources: 3, 9, 12
Finally, it should be borne in mind that genetic factors only make up a small proportion of the overall effect of lithium on telomere length and structure. It is difficult to interpret the effects of other factors such as age - specific changes in telomerase activity, given the age of each individual. Sources: 3, 6
Although it can take months or years for telomeres to change significantly, the authors write, "we should focus on maintaining healthy habits rather than being obsessed with telomerase activity at a certain point in time or telomere length," they write. It seems to be a matter of time before you stay healthy, not if you get an illness or actually die, but rather when. Sources: 15, 17
Previous laboratory and epidemiological findings support several plausible biological pathways, including changes in cell and immune function [22], and maternal stress during pregnancy is associated with shorter offspring telomeres [23]. However, this work does not cover cellular aging, such as telomerase length, as a marker. Finally, the study did not include an analysis of newborn telomere length, but was conducted in mammals, particularly in humans, which have little or no somatic telomerase production. Sources: 0, 8, 18
The current data show the importance of telomere length as a biomarker of cellular aging in the development of Alzheimer's disease. We are now studying dementia sufferers and seeing how various ways of reducing their stress can improve the biomarkers of ageing, including telomerase length. Sources: 8, 17
The possibility of offering telomere length as part of a genetic test is intriguing, because the genetic material that protects telomeres is protected by telomerase, the enzyme responsible for repairing the chromosomes in the cell. Sources: 13
Comparative genomic work has shown that lithium can moderate the expression of genes that control telomere length, and this may be a mechanism by which lithium prolongs telomeres in patients with bipolar disorder. This novel telomerase loop mechanism implies that progressive teliter shortening can affect cell physiology and age-related diseases, such as aging, as telomeres become incurably short and trigger DNA damage signals. Lifestyle is an important factor in telomyelitis, a disease of the heart, brain and spinal cord, so length could be an important determinant of a patient's long-term wellbeing. It might explain how some of us age more or less than others, with decisions we make every day. 

Cited Sources